Which of the following is a differential diagnosis for Cushings syndrome?
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Swearingen B, Biller B. (eds). Diagnosis and Management of Pituitary Disorders, Totowa, NJ: Humana Press; 2008, 475.pp. Show
JOURNAL ARTICLES Laws ER Jr, Catalino MP, Machine learning and artificial intelligence applied to the diagnosis and management of Cushing disease. Neurosurg Focus. 2020; 48; 1-3. Wang,F, Catalino M, Bi WL, Dunn IF, Smith TR, Guo Y, Hordejuk D, Kaiser U, Laws, ER. Post-operative day one morning cortisol as a biomarker to predict long-term remission of Cushing disease. J Clin Endocrinol Metabol, 2020. Burke WT, Penn DL, Repetti, CS, Iuliano, S, Laws ER. Outcomes for repeat transspnenoidal surgery for recurrent Cushings’s disease: Updated. Neurosurgery. 2019; 6:E1030-1036 PMID 31140553 Bunevicius A, Laws ER, Vance, ML, Iuliano S, Sheehan, J. Surgical and radiosurgical treatment strategies in Cushing’s disease. Journal of Neuro-Oncology. 2019 doi: 110.1007/s 11060-019-03325-6 Theodoropoulou M, Reincke M. Tumor-directed therapeutic targets in Cushing disease. J Clin Endocrinol Metab, 2019; 104:925-933. Zaidi HA, Penn DL, Cote DJ, Laws ER Jr, Root cause analysis of diagnostic and surgical failures in the treatemnt of suspected Cushing’s disease. J Clin Neurosci. 2018; 53: 153-159. Smith TR., Hulou MM, Huang KT, et al. Complications after transsphenoidal surgery for patients with Cushing’s disease and silent corticotroph adenomas. Neurosurg Focus 2015;38(2):E12. Iuliano S L. and Laws, Jr. ER. Early recognition of Cushing’s disease: a case study. J Am Assoc Nurse Pract. 2013;25(8): 402-406. Starke RM., Reames DL, Chen CJ, Laws ER and Jane JA, Jr. Endoscopic transsphenoidal surgery for cushing disease: techniques, outcomes, and predictors of remission. Neurosurgery 2013; 72(2): 240-247; discussion 247. https://www.ncbi.nlm.nih.gov/pubmed/23149974 Lodish M, Dunn SV, Sinaii N, Keil MF, Stratakis CA. Recovery of the hypothalamic-pituitary-adrenal axis in children and adolescents after surgical cure of Cushing’s disease.J Clin Endocrinol Metab. 2012;97(5):1483-91 http://www.ncbi.nlm.nih.gov/pubmed/22399509 Castinetti F, Morange I, Conte-Devolx B, Brue T. Cushing’s disease. Orphanet J Rare Dis. 2012;7(1):41. http://www.ncbi.nlm.nih.gov/pubmed/22710101 Aytug S., Laws ER Jr., and Vance ML Assessment of the utility of the high-dose dexamethasone suppression test in confirming the diagnosis of Cushing disease. Endocr Pract. 2012;18(2):152-157. https://www.ncbi.nlm.nih.gov/pubmed/21856594 Tritos NA, Biller BM. Advances in medical therapies for Cushing’s syndrome. Discov Med. 2012;13(69):171-9. http://www.ncbi.nlm.nih.gov/pubmed/22369976 Fleseriu M, Biller BM, Findling JW, Molitch ME, Schteingart DE, Gross C; SEISMIC Study Investigators. Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing’s syndrome. J Clin Endocrinol Metab. 2012;97(6):2039-49. http://www.ncbi.nlm.nih.gov/pubmed/22466348 Zemskova MS, Gundabolu B, Sinaii N, et al. Utility of various functional and anatomic imaging modalities for detection of ectopic adrenocorticotropin-secreting tumors. J Clin Endocrinol Metab. 2010 Mar;95(3):1207-19. http://www.ncbi.nlm.nih.gov/pubmed/20089611 Pivonello R, De Martino MC, et al. The medical treatment of Cushing’s disease: effectiveness of chronic treatment with the dopamine agonist cabergoline in patients unsuccessfully treated by surgery. J Clin Endocrinol Metab. 2009;94(1):223-30. http://www.ncbi.nlm.nih.gov/pubmed/18957500 Newell-Price J. Diagnosis/differential diagnosis of Cushing’s syndrome: a review of best practice. Best Pract Res Clin Endocrinol Metab. 2009;23 Suppl 1:S5-14. http://www.ncbi.nlm.nih.gov/pubmed/20129193 Nieman LK, Biller BM, Findling JW, et al. The diagnosis of Cushing’s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008 May;93(5):1526-40. http://www.ncbi.nlm.nih.gov/pubmed/18334580 Prevedello DM, Pouratian N, Sherman J, Jane JA Jr, Vance ML, Lopes MB, Laws ER Jr.. Management of Cushing’s disease: outcome in patients with microadenoma detected on pituitary magnetic resonance imaging. J Neurosurg. 2008;109(4):751-759. Patil CG, Veeravagu A, Prevedello DM, Katznelson L, Vance ML, Laws ER Jr. Outcomes after repeat transsphenoidal surgery for recurrent Cushing’s disease. Neurosurgery. 2008 Aug;63(2):266-70; discussion 270-1. Patil CG, Prevedello DM, Lad SP, Vance ML, Thorner MO, Katznelson L, Laws ER Jr. Late recurrences of Cushing’s disease after initial successful transsphenoidal surgery.”. J Clin Endocrinol Metab. 2008 Feb;93(2):358-62. Epub 2007 Dec 4. Biller BM, Grossman AB, Stewart PM, et al. Treatment of adrenocorticotropin-dependent Cushing’s syndrome: a consensus statement. J Clin Endocrinol Metab. 2008;93(7):2454-62. http://www.ncbi.nlm.nih.gov/pubmed/18413427 Lad SP, Patil CG, Laws ER Jr, Katznelson L. The role of inferior petrosal sinus sampling in the diagnostic localization of Cushing’s disease. Neurosurg Focus. 2007;23(3):E2. Batista DL, Riar J, Keil M, Stratakis CA. Diagnostic tests for children who are referred for the investigation of Cushing syndrome. Pediatrics. 2007;120(3):e575-86. http://www.ncbi.nlm.nih.gov/pubmed/17698579 Kanter AS, Diallo AO, Jane JA Jr, Sheehan JP, Asthagiri AR, Oskouian RJ, Okonkwo DO, Sansur CA, Vance ML, Rogol AD, Laws ER Jr. Single-center experience with pediatric Cushing’s disease. J Neurosurg. 2005 Nov;103(5 Suppl):413-20. De Tommasi C, Vance ML, Okonkwo DO, Diallo A, Laws ER Jr. Surgical management of adrenocorticotropic hormone-secreting macroadenomas: outcome and challenges in patients with Cushing’s disease or Nelson’s syndrome. J Neurosurg. 2005;Nov;103(5):825-30. Locatelli M, Vance ML, Laws ER. Clinical review: the strategy of immediate reoperation for transsphenoidal surgery for Cushing’s disease. J Clin Endocrinol Metab. 2005 Sep;90(9):5478-82. Epub 2005 Jun 14. Sonino N, Fava GA. Psychiatric disorders associated with Cushing’s syndrome. Epidemiology, pathophysiology and treatment. CNS Drugs. 2001;15(5):361-73. http://www.ncbi.nlm.nih.gov/pubmed/11475942 Colao A, Faggiano A, Pivonello R, et al. Inferior petrosal sinus sampling in the differential diagnosis of Cushing’s syndrome: results of an Italian multicenter study. Eur J Endocrinol. 2001;144(5):499-507. http://www.ncbi.nlm.nih.gov/pubmed/11331216 Savage MO, Lienhardt A, Lebrethon MC, et al. Cushing’s disease in childhood: presentation, investigation, treatment and long-term outcome. Horm Res. 2001;55 Suppl 1:24-30. http://www.ncbi.nlm.nih.gov/pubmed/11408758 Chrousos GP. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int J Obes Relat Metab Disord. 2000;24 Suppl 2:S50-55. http://www.ncbi.nlm.nih.gov/pubmed/10997609 Lindholm J. Cushing’s syndrome: historical aspects. Pituitary. 2000 Oct;3(2):97-104. INTERNET Cushing syndrome. MedlinePlus. Review Date 5/6/2019. Cushing’s Syndrome. National Endocrine and Metabolic Diseases Information Service. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Last Reviewed May 2018. https://www.niddk.nih.gov/health-information/endocrine-diseases/cushings-syndrome Accessed July 22, 2021. What can be mistaken for Cushing syndrome?Cushing's syndrome may be mistaken for other conditions that have many of the same signs, such as polycystic ovary syndrome or metabolic syndrome. Your doctor will first want to rule out other conditions. Diagnosis is based on your medical history, a physical exam, and lab tests.
Which tests are helpful for differential diagnosis between Cushing disease and Cushing syndrome?In conclusion, our study confirms that CRH test, DDAVP test and HDDST have high accuracy in the differential diagnosis of ACTH-dependent CS. In particular, the combination of CRH test and HDDST allows to achieve the best performance in terms of sensitivity and specificity.
Which of the following are part of the differential diagnosis of cyclic Cushing's syndrome?Differential diagnosis of cyclic Cushing's syndrome should include: exogenous steroid use, mild autonomous hypercortisolemia (previously referred to as subclinical Cushing's syndrome), non-neoplastic hypercortisolemia, use of xenobiotics affecting hormonal tests, glucocorticoid resistance syndrome, and factitious ...
What is the difference between Cushing's syndrome and Addison's disease?What's the difference between Addison's disease and Cushing's syndrome? Addison's disease happens when your body doesn't have enough cortisol (and aldosterone), whereas Cushing's syndrome happens when your body has too much cortisol (hypercortisolism).
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