What is the difference between a biotechnology company and a pharmaceutical company?

30 June 2020

Most approved “priority” medicines are developed by biotech rather than large pharmaceutical firms, says a two-decade study at the University of Cambridge Judge Business School.

What is the difference between a biotechnology company and a pharmaceutical company?

Biotech companies created 40 per cent more US Food & Drug Administration-approved “priority” drugs than the entire pharmaceutical industry from 1998 through 2016 while spending less than half as much, says a study at Cambridge Judge Business School published in the latest issue of California Management Review.

What is the difference between a biotechnology company and a pharmaceutical company?
Dr Nektarios (Aris) Oraiopoulos

The study is based on a novel dataset that traces each company that originally created the 524 products approved by the FDA during the 19-year study period – of which 237 were priority-review products and 287 were standard-review products.

Of the 237 priority-review products, 138 originated from biotech companies and 99 from pharmaceutical companies.

“Priority” approvals are issued by the FDA for new drugs that not only treat life-threatening conditions but also provide “significant improvements” in safety or effectiveness compared to existing treatments. “When the public thinks about medical breakthroughs – something that moves medicine forward in an important way – these priority-review products are likely to be the discoveries it has in mind,” says the study in the Spring 2020 issue of California Management Review co-authored by Donald Drakeman, Fellow, and Dr Nektarios Oraiopoulos, University Lecturer, at Cambridge Judge Business School.

The study estimates that the pharmaceutical industry spent a total of $1.6 trillion on research & development (R&D) and the biotechnology industry spent $627 billion around the same time period as the study.

“A common limitation of many R&D performance studies is the lack of a commonly accepted metric of how to measure the innovativeness of a new product,” the journal article says. “Our study overcomes this challenge by looking at an objective criterion that applies equally to all the companies: the status of first-ever FDA approval of new molecular entities” in the form of priority or standard approvals.

What is the difference between a biotechnology company and a pharmaceutical company?
Don Drakeman

The study says the findings reflect the often different approaches of established pharmaceutical companies and smaller biotech firms funded by venture capitalists and other life sciences investors. While large pharmaceutical firms often invest in bigger and more focused portfolios, biotech firms make more, smaller bets and quickly abandon failing projects. The new research highlights the role of this “biotech ecosystem” in providing funding for such a highly diversified portfolio, finding that the biotech industry initiated nearly five times as many projects as the pharmaceutical industry (39,619 compared to 8,377) around the same time period of the study.

While large corporate R&D teams may be expert in managing product development pathways, they need to “avoid falling into the trap of narrowing the funnel too quickly” and missing out on the next blockbuster product “because it did not fit today’s strategic criteria”, the study says.

The study – entitled “The Risk of De-Risking Innovation: Optimal R&D Strategies in Ambiguous Environments” – is co-authored by Donald Drakeman, a Fellow in Operations and Technology Management at Cambridge Judge Business School and a Venture Partner at Advent Life Sciences, and Dr Nektarios Oraiopoulos, University Lecturer and the Director of the MPhil Programme in Strategy, Marketing & Operations at Cambridge Judge Business School.

  • What is the difference between a biotechnology company and a pharmaceutical company?

    When I began this job a few months ago I found myself hearing the words pharmaceutical and biotech quite often. I myself am not a science person by any means, so these words didn’t mean too much to me.  I knew that they referred to companies that deal with drugs, but that was the extent of it, I really, barely knew anything more about them.  I decided today that I was going to find out what those companies are doing and the difference, if any, between the two.

    So, I began my search and these are the two definitions I came across:

    • Biotech Companies: a company whose products or services primarily use biotechnology methods for their production, design or delivery. a company that uses live organisms or their products, such as bacteria or enzymes, to manufacture drugs.
    • Pharmaceutical Companies: a company that researches, develops, tests, manufactures, and/or sells medical drugs or devices. a commercial business licensed to research, develop, market and/or distribute drugs, most commonly in the context of healthcare.

    Unfortunately, these definitions are rather bland and make the two company types sound very similar. So, are Biotech and Pharmaceutical companies the same thing?  Maybe not…  I have compiled a differences chart to help paint a clearer picture about the two types of companies:

    Pharmaceutical Biotech
    Size Large to middle sized Small start-up
    Business Model Large business Small business
    Development Process Empirical screening Genetic engineering
    Basis of Research Plants, microbes, and organisms RNA, DNA, Amino Acids, and hormones
    Specialty Drug refinement Drug discovery
    Financing Shareholders Private investors
    Business Approach Low risk High risk

    Recent speculation among industry experts states that there is no clear distinction between the two types of companies.  However, my research proves otherwise. Biotechnology and pharmaceutical companies both produce medicines, but the medicines made by biotechnology companies are derived from living organisms while those made by pharmaceutical companies generally have a chemical basis. Biotech companies are typically developing large molecule drugs and have novel intellectual property or some new technology that make for an attractive pipeline to develop into a commercially viable product, but usually not the scale in sales and marketing to make this happen. Working with plant and chemical based compounds, pharmaceutical companies work their magic to make medicines that cure or manage diseases, and protect us from infection.

Is biotechnology part of pharmaceutical industry?

Pharmaceutical biotechnology is a relatively new and growing field in which the principles of biotechnology are applied to the development of drugs. A majority of therapeutic drugs in the current market are bioformulations, such as antibodies, nucleic acid products and vaccines.

What is the role of biotechnology in pharmaceutical industry?

Biotechnology helps the pharmaceutical industry to develop new products, new processes, methods and services and to improve existing ones. Thus, international competitiveness can be strengthened, new jobs can be created and existing jobs preserved.

What is the difference between a biopharmaceutical company and a pharmaceutical company?

The main difference comes down to product manufacturing. Biopharmaceutical products are manufactured in living organisms, including white blood cells or bacteria. On the flip side, pharmaceutical products are manufactured using chemical-based processes.

Which is best pharma or biotechnology?

Both options are good, but you need to find out your interest and liking. If select B. Pharma you need to be good at Chemistry specially organic chemistry. If you opt for Biotechnology you should have interest in technology and you should good at physics, maths & have interest in machinery.