A client who has just tested positive for human immunodeficiency virus

People are diagnosed with AIDS when they have certain signs or symptoms defined by the U.S. Centers for Disease Control and Prevention (CDC). The CDC's definition of AIDS includes:

  • Less than 200 CD4+ T cells per cubic millimeter of blood, compared with about 1,000 CD4+ T cells for healthy people. CD4+T cells are white blood cells that play an important role in the body's immune system. These cells are destroyed by HIV. Even when a HIV-positive person feels well and is not experiencing any symptoms of the disease, CD4+ T cells are being infected by HIV.
  • CD4+ T cells accounting for less than 14 percent of all lymphocytes, a type of white blood cell.

One of more of the illnesses listed below:

  • Candidiasis of bronchi, esophagus, trachea or lungs
  • Cervical cancer that is invasive
  • Coccidioidomycosis that has spread
  • Cryptococcosis that is affecting the body outside the lungs
  • Cryptosporidiosis affecting the intestines and lasting more than a month
  • Cytomegalovirus disease outside of the liver, spleen or lymph nodes
  • Cytomegalovirus retinitis that occurs with vision loss
  • Encephalopathy that is HIV-related
  • Herpes simplex including ulcers lasting more than a month or bronchitis, pneumonitis or esophagitis
  • Histoplasmosis that has spread
  • Isosporiasis affecting the intestines and lasting more than a month
  • Kaposi's sarcoma
  • Lymphoma that is Burkitt type, immunoblastic or that is primary and affects the brain or central nervous system
  • Mycobacterium avium complex or disease caused by M kansasii
  • Mycobacterium tuberculosis in or outside the lungs
  • Other species of mycobacterium that has spread
  • Pneumocystis jiroveci, formerly called carinii, pneumonia
  • Pneumonia that is recurrent
  • Progressive multifocal leukoencephalopathy
  • Salmonella septicemia that is recurrent
  • Toxoplasmosis of the brain, also called encephalitis
  • Wasting syndrome caused by HIV infection

Symptoms also may include anxiety, dementia, depression and insomnia.

Tests for HIV and AIDS

Blood tests are the most common way to diagnose the human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). These tests look for antibodies to the virus that are present in the blood of infected individuals. People exposed to the virus should get tested immediately.

Early testing is crucial with HIV. If you test positive for the virus, you and your doctor can develop a treatment plan to help fight HIV and ward off complications. Early testing also can alert you to avoid high-risk behavior that could spread the virus to others.

Because it can take from six weeks to six months to develop antibodies to the virus, follow-up tests may be needed. Your doctor will ask about your symptoms, medical history and risk factors and perform a physical examination.

Acquired immunodeficiency syndrome (AIDS) is a chronic, potentially life-threatening condition caused by the human immunodeficiency virus (HIV). By damaging your immune system, HIV interferes with your body's ability to fight infection and disease.

HIV is a sexually transmitted infection (STI). It can also be spread by contact with infected blood and from illicit injection drug use or sharing needles. It can also be spread from mother to child during pregnancy, childbirth or breastfeeding. Without medication, it may take years before HIV weakens your immune system to the point that you have AIDS.

There's no cure for HIV/AIDS, but medications can control the infection and prevent progression of the disease. Antiviral treatments for HIV have reduced AIDS deaths around the world, and international organizations are working to increase the availability of prevention measures and treatment in resource-poor countries.

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Symptoms

The symptoms of HIV and AIDS vary, depending on the phase of infection.

Primary infection (Acute HIV)

Some people infected by HIV develop a flu-like illness within 2 to 4 weeks after the virus enters the body. This illness, known as primary (acute) HIV infection, may last for a few weeks.

Possible signs and symptoms include:

  • Fever
  • Headache
  • Muscle aches and joint pain
  • Rash
  • Sore throat and painful mouth sores
  • Swollen lymph glands, mainly on the neck
  • Diarrhea
  • Weight loss
  • Cough
  • Night sweats

These symptoms can be so mild that you might not even notice them. However, the amount of virus in your bloodstream (viral load) is quite high at this time. As a result, the infection spreads more easily during primary infection than during the next stage.

Clinical latent infection (Chronic HIV)

In this stage of infection, HIV is still present in the body and in white blood cells. However, many people may not have any symptoms or infections during this time.

This stage can last for many years if you're receiving antiretroviral therapy (ART). Some people develop more severe disease much sooner.

Symptomatic HIV infection

As the virus continues to multiply and destroy your immune cells — the cells in your body that help fight off germs — you may develop mild infections or chronic signs and symptoms such as:

  • Fever
  • Fatigue
  • Swollen lymph nodes — often one of the first signs of HIV infection
  • Diarrhea
  • Weight loss
  • Oral yeast infection (thrush)
  • Shingles (herpes zoster)
  • Pneumonia

Progression to AIDS

Access to better antiviral treatments has dramatically decreased deaths from AIDS worldwide, even in resource-poor countries. Thanks to these life-saving treatments, most people with HIV in the U.S. today don't develop AIDS. Untreated, HIV typically turns into AIDS in about 8 to 10 years.

When AIDS occurs, your immune system has been severely damaged. You'll be more likely to develop diseases that wouldn't usually cause illness in a person with a healthy immune system. These are called opportunistic infections or opportunistic cancers.

The signs and symptoms of some of these infections may include:

  • Sweats
  • Chills
  • Recurring fever
  • Chronic diarrhea
  • Swollen lymph glands
  • Persistent white spots or unusual lesions on your tongue or in your mouth
  • Persistent, unexplained fatigue
  • Weakness
  • Weight loss
  • Skin rashes or bumps

When to see a doctor

If you think you may have been infected with HIV or are at risk of contracting the virus, see a health care provider as soon as possible.

More Information

  • Early HIV symptoms: What are they?

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What does human immunodeficiency virus positive mean?

HIV (human immunodeficiency virus) is a virus that damages the cells in your immune system and weakens your ability to fight everyday infections and disease.

What happens to a person whose cells are infected by human immunodeficiency virus?

HIV infects and destroys certain white blood cells called CD4+ cells. If too many CD4+ cells are destroyed, the body can no longer defend itself against infection. The last stage of HIV infection is AIDS (acquired immunodeficiency syndrome).