Breast cancer research topics

Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy

Elevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of collagen, one of the main fibrous proteins present in breast stroma, has been...

Authors: Clara Bodelon, Maeve Mullooly, Ruth M. Pfeiffer, Shaoqi Fan, Mustapha Abubakar, Petra Lenz, Pamela M. Vacek, Donald L. Weaver, Sally D. Herschorn, Jason M. Johnson, Brian L. Sprague, Stephen Hewitt, John Shepherd, Serghei Malkov, Patricia J. Keely, Kevin W. Eliceiri

18F-fluorodeoxyglucose [FDG] PET or 18F-fluorothymidine [FLT] PET to assess early response to aromatase inhibitors [AI] in women with ER+ operable breast cancer in a window-of-opportunity study

This study evaluated the ability of 18F-Fluorodeoxyglucose [FDG] and 18F-Fluorothymidine [FLT] imaging with positron emission tomography [PET] to measure early response to endocrine therapy from baseline to just ...

Authors: Perrin E. Romine, Lanell M. Peterson, Brenda F. Kurland, Darrin W. Byrd, Alena Novakova-Jiresova, Mark Muzi, Jennifer M. Specht, Robert K. Doot, Jeanne M. Link, Kenneth A. Krohn, Paul E. Kinahan, David A. Mankoff and Hannah M. Linden

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breas...

Authors: Anna Morra, Maria Escala-Garcia, Jonathan Beesley, Renske Keeman, Sander Canisius, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Paul L. Auer, Annelie Augustinsson, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Stig E. Bojesen

Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation

Diagnostic ionizing radiation is a risk factor for breast cancer [BC]. BC risk increases with increased dose to the chest and decreases with increased age at exposure, with possible effect modification related...

Authors: Maximiliano Ribeiro Guerra, Juliette Coignard, Séverine Eon-Marchais, Marie-Gabrielle Dondon, Dorothée Le Gal, Juana Beauvallet, Noura Mebirouk, Muriel Belotti, Olivier Caron, Marion Gauthier-Villars, Isabelle Coupier, Bruno Buecher, Alain Lortholary, Jean-Pierre Fricker, Paul Gesta, Catherine Noguès

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